TGPred is a web server which provides Tumor Gene Prediction tools, including 3D protein structure prediction, ligand binding site prediction, and the functional spatial hotspot variation forecast, as well as the estimation of functional impacts of mutations.

1. Predict functional impacts of certain mutations by using PROVEAN.
2. Search for wild type protein structure from PDB or predict it with I-TASSER.
3. Predict ligand binding sites of wild type protein using COACH, a module of I-TASSER.
4. Predict spatial hotspot variations using HotSpot3D.
5. Predict variant protein structure involving mutations using RASP.
6. Predict variant protein structure involving deletions or insertions using I-TASSER.

1. 从PDB数据库获取或预测野生型蛋白的三维结构

Example of submitted sequence of TP53:
>Protein sequence of TP53
YSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSD

Example of amino acid variations of TP53:
M8K-p.M133K
F9L-p.F134L
P26S-p.P151S

2020 - Version 1.0 including the following functions:

3D protein structure prediction, ligand binding site prediction, and the functional spatial hotspot variation forecast, as well as the estimation of functional impacts of mutations.

Please cite the following article when you use TGPred server.
Jixiang Liu, Wei Liu, Xueling Li, Quanxue Li, Wentao Dai, Yuan-Yuan Li. (2020). TGPred: a Tumor Gene Prediction webserver for analyzing structural and functional impacts of variants. Journal of Molecular Cell Biology. doi: 10.1093/jmcb/mjaa007.